Sarcoidosis

Laboratory investigation

Bone profile, looking for hypercalcaemia

Occurs in ~10% of cases

Elevated serum ACE

60% sensitivity, 70% specificity

Also can be used for disease monitoring

Radiological investigations

Radiological stages of sarcoidosis

Stage 1: Bilateral hilar lymphadenopathy

Stage 2: Bilateral hilar lymphadenopathy and interstitial infiltrates

Stage 3: Interstitial infiltrates

Stage 4: Pulmonary fibrosis

Further investigations

Spirometry

Investigate for restrictive picture

Variants

Lofgren's syndrome is an acute form sarcoidosis characterised by bilateral hilar lymphadenopathy (BHL), erythema nodosum, fever and polyarthralgia. It typically occurs in young females and carries an excellent prognosis.
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