Idiopathic Thrombocytopenic Purpura

Idiopathic thrombocytopenic purpura (ITP) is an immune mediated reduction in the platelet count. Antibodies are directed against the glycoprotein IIb-IIIa or Ib complex

Laboratory Investigations



antiplatelet autoantibodies (usually IgG)

bone marrow aspiration shows megakaryocytes in the marrow. This should be carried out prior to the commencement of steroids in order to rule out leukaemia


oral prednisolone (80% of patients respond)
splenectomy if platelets < 30 after 3 months of steroid therapy
IV immunoglobulins
immunosuppressive drugs e.g. cyclophosphamide

Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License