Hyponatraemia

Presentation

Cerebral dysfunction (restlessness, irritability, drowsiness, delirium)

Muscular dysfunction (generalized weakness, myoclonus, tremor, asterixis, hyporeflexia, ataxia, dysarthria, Cheyne-Stokes respiration, pathologic reflexes)

In extreme cases: seizures (generalised), coma

The degree of symptoms tends to be due to the rate of change of [Na+], more than the concentration

Differential diagnosis

SIADH

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