Haemolytic Uraemic Syndrome (HUS)

Haemolytic uraemic syndrome is generally seen in young children and produces a triad of:
acute renal failure
microangiopathic haemolytic anaemia
thrombocytopenia

Causes
post-dysentery - classically E coli 0157:H7 ('verotoxigenic', 'enterohaemorrhagic')
tumours
pregnancy
ciclosporin, the Pill
systemic lupus erythematosus
HIV

Investigations
full blood count: anaemia, thrombocytopaenia, fragmented blood film
U&E: acute renal failure
stool culture

Management
treatment is supportive e.g. Fluids, blood transfusion and dialysis if required
there is no role for antibiotics, despite the preceding diarrhoeal illness in many patients
the indications for plasma exchange in HUS are complicated. As a general rule plasma exchange is reserved for severe cases of HUS not associated with diarrhoea

Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License