Chronic Lymphocytic Leukaemia

Chronic lymphocytic leukaemia (CLL) is caused by a monoclonal proliferation of well-differentiated lymphocytes which are almost always B-cells (99%)

Features
often none
constitutional: anorexia, weight loss
bleeding, infections
lymphadenopathy more marked than CML

Complications
hypogammaglobulinaemia leading to recurrent infections
warm autoimmune haemolytic anaemia in 10-15% of patients
transformation to high-grade lymphoma (Richter's transformation)

Investigations
Blood film: smudge cells (also known as smear cells)
immunophenotyping - CD19, and often CD5 and CD23

Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License